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Genetics

Diagnosing Disease with Bioinformatics

In an era of DNA sequencing and new molecular biology techniques, scientists have become inundated with biological data. The interdisciplinary field of bioinformatics combines biology, computer science, mathematics, and statistics to overcome this challenge by creating methods of analyzing the wealth of biological data publicly available in databases, such as UniProt and NCBI.

In this lab, students will receive a hands-on introduction to this cutting-edge field, learning the importance of using novel technologies to diagnose and treat diseases with a genetic basis. Using a brief list of symptoms and their newfound knowledge regarding bioinformatics, students will diagnose two patients, Patient X and Patient Y, while compiling information about the proteins involved in their respective diseases.

Students will:
  • Engage in the engineering design and iterative process
  • Analyze complex real-world problems through a biological lens
  • Follow specific criteria in order to problem solve by making informed and specific search queries
  • Discover and understand the importance of bioinformatics and sequencing to diagnose and treat diseases
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    Lab time commitment

    90-100 minutes (including 25-minute intro video)

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    Lab materials

    Digital materials only

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    Live Q&A session and wrap up with

    College Students & Professional Engineers

Join our Lab Day event!

Learn about Lab Days
speaker-photo
October 10, 2025
Tamara Robertson

Emmy-nominated producer & TV host

Mythbusters, Mythbusters Jr., and Scijinks

Learn more

Classroom Tools & Resources

Get access to all of the presentation materials, workbooks and resources to run the Genetics lab in your classroom.

Meet the lab intro host

Sarah Syed
PhD Student ,
Harvard–MIT

Sarah Syed is a recent graduate of the Massachusetts Institute of Technology, where she earned undergraduate degrees in biological engineering and business management with a minor in biology. Inspired by her grandmother’s work as an OB-GYN in Pakistan, Sarah aspires to start a biotech company developing accessible interventions for historically overlooked diseases affecting women’s health.

Sarah has been engaged in various forms of research since the fifth grade. At MIT, she studied mechanisms of horizontal gene transfer at the Grossman Lab and developed nanoscale contrast agents for early cancer detection at the Laboratory for Regenerative Multi-Scale Technologies. At the Center for Gynepathology Research, she investigated the impact of the innate immune system on endometriosis, with the goal of uncovering novel treatment strategies. Previously, Sarah led the differentiation of gene-edited stem cells for allogeneic cell therapy as an intern at CRISPR Therapeutics, launched startups addressing critical issues in women’s health at Aegis Ventures, and guided the commercialization of innovative biotech solutions as a healthcare strategy consultant at Kx Advisors. Alongside her scientific background, she consistently seeks to contextualize her efforts within a broader mission for change, drawing on her experiences as a teacher and nonprofit leader. Sarah is currently pursuing her PhD in Medical Engineering and Medical Physics at Harvard and MIT’s joint Health Sciences and Technology program.

Sarah Syed

PhD Student

Sarah Syed is a recent graduate of the Massachusetts Institute of Technology, where she earned undergraduate degrees in biological engineering and business management with a minor in biology. Inspired by her grandmother’s work as an OB-GYN in Pakistan, Sarah aspires to start a biotech company developing accessible interventions for historically overlooked diseases affecting women’s health.

Sarah has been engaged in various forms of research since the fifth grade. At MIT, she studied mechanisms of horizontal gene transfer at the Grossman Lab and developed nanoscale contrast agents for early cancer detection at the Laboratory for Regenerative Multi-Scale Technologies. At the Center for Gynepathology Research, she investigated the impact of the innate immune system on endometriosis, with the goal of uncovering novel treatment strategies. Previously, Sarah led the differentiation of gene-edited stem cells for allogeneic cell therapy as an intern at CRISPR Therapeutics, launched startups addressing critical issues in women’s health at Aegis Ventures, and guided the commercialization of innovative biotech solutions as a healthcare strategy consultant at Kx Advisors. Alongside her scientific background, she consistently seeks to contextualize her efforts within a broader mission for change, drawing on her experiences as a teacher and nonprofit leader. Sarah is currently pursuing her PhD in Medical Engineering and Medical Physics at Harvard and MIT’s joint Health Sciences and Technology program.

Lab Day Keynote

Every Engineering Tomorrow Lab Day event ends with an inspiring keynote from an engineering expert. Watch this one from the latest Genetics Lab Day.

Valentin Sluch

Cell Biology Scientist and Associate Director
CRISPR

WHY ENGINEERING TOMORROW
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Hands-on student activities get students excited and keep them engaged.
Cutting-edge instruction designed by professional engineers.
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